Overall H+/ATP (H+/P) ratio for oxidative phosphorylation in vivo

Value 3 unitless
Organism Eukaryotes
Reference Brand MD, Lehninger AL. H+/ATP ratio during ATP hydrolysis by mitochondria: modification of the chemiosmotic theory. Proc Natl Acad Sci U S A. 1977 May74(5):1955-9. p.1957 right column 2nd paragraph & p.1958 left column top paragraph & right column 2nd paragraphPubMed ID17116
Comments "A scheme that accommodates the available evidence on proton movements, including the difference between the H+/site and the H+/ATP ratios from pulse methods, is shown in Fig. 5 (see ref. 30). [Researchers] propose that 3 H+ are ejected during passage of an electron-pair through each energy-conserving site and that 2 H+ are then translocated inward by the mitochondrial ATPase to make possible the formation of one molecule of ATP per site in the matrix. The third H+ ejected is utilized to drive the energy-requiring transport of ADP and Pi into the mitochondria and the coupled export of ATP to the cytosol. In this way the overall H+/ATP ratio for oxidative phosphorylation in vivo, including the transport steps, is 3.0 and equal to the H+/site ratio."
Entered by Uri M
ID 110658