| Comments |
"A scheme that accommodates the available evidence on
proton movements, including the difference between the
H+/site and the H+/ATP ratios from pulse methods, is shown
in Fig. 5 (see ref. 30). [Researchers] propose that 3 H+ are ejected during
passage of an electron-pair through each energy-conserving site
and that 2 H+ are then translocated inward by the mitochondrial
ATPase to make possible the formation of one molecule of ATP per site in the matrix. The third H+ ejected is utilized to drive the energy-requiring transport of ADP and Pi into the
mitochondria and the coupled export of ATP to the cytosol. In this way the overall H+/ATP ratio for oxidative phosphorylation in vivo, including the transport steps, is 3.0 and equal to
the H+/site ratio." |