| Range |
<5.2 in the mouse: <6.6 in the rat unitless
|
| Organism |
Rodent |
| Reference |
McConnell EL, Basit AW, Murdan S. Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments. J Pharm Pharmacol. 2008 Jan60(1):63-70. AbstractPubMed ID18088506
|
| Method |
"The contents of each gastrointestinal section were removed,
mixed and the pH was determined using a pre-calibrated pH
211 Microprocessor pH Meter (Hanna Instruments)." |
| Comments |
"The mean intestinal pH [of mouse & rat] was lower than that in man (<pH 5.2 in the mouse <pH 6.6 in the rat). This brings into question the use of rodents in investigations on enteric-coated drug carriers targeted to the large intestine/distal gut." |
| Entered by |
Uri M |
| ID |
110516 |