Gastric pH fasted and after meal ingestion

Range fasted 1.7: fed 5.0 unitless
Organism Human Homo sapiens
Reference McConnell EL, Basit AW, Murdan S. Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments. J Pharm Pharmacol. 2008 Jan60(1):63-70. p.65 right columnPubMed ID18088506
Primary Source Dressman et al., (1990) Upper gastrointestinal (GI) pH in young, healthy men and women. Pharm. Res. 7: 756–761 & Russell et al., (1993) Upper gastrointestinal pH in seventy-nine healthy, elderly North American men and women. Pharm. Res. 10: 187–196PubMed ID2395805, 8456064
Comments "In both animals [rat and mouse], the stomach pH appeared higher in the fasted state (3.9 compared with 3.2 in rats and 4.0 compared with 3.0 in mice, BNID 110513), although the difference was only statistically significant in the mouse. Higher pH in the fasted state was surprising given that, in man, the fasted gastric pH is lower than the fed gastric pH (fasted pH 1.7 increasing to 5.0 after meal ingestion in healthy subjects (primary sources)) due to the buffering effects of food (Malagelada et al 1976). However, this was dependent on the meal type, with high protein meals having increased buffering effect over an isocalorific carbohydrate meal (Richardson et al 1976)."
Entered by Uri M
ID 110514