| Range |
fasted 1.7: fed 5.0 unitless
|
| Organism |
Human Homo sapiens |
| Reference |
McConnell EL, Basit AW, Murdan S. Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments. J Pharm Pharmacol. 2008 Jan60(1):63-70. p.65 right columnPubMed ID18088506
|
| Primary Source |
Dressman et al., (1990) Upper gastrointestinal (GI) pH in young, healthy men and women. Pharm. Res. 7: 756–761 & Russell et al., (1993) Upper gastrointestinal pH in seventy-nine healthy, elderly North American men and women. Pharm. Res. 10: 187–196PubMed ID2395805, 8456064
|
| Comments |
"In both animals [rat and mouse], the stomach pH appeared higher in the fasted
state (3.9 compared with 3.2 in rats and 4.0 compared with
3.0 in mice, BNID 110513), although the difference was only statistically
significant in the mouse. Higher pH in the fasted state was
surprising given that, in man, the fasted gastric pH is lower
than the fed gastric pH (fasted pH 1.7 increasing to 5.0 after
meal ingestion in healthy subjects (primary sources)) due to the buffering effects of food
(Malagelada et al 1976). However, this was dependent on the
meal type, with high protein meals having increased buffering
effect over an isocalorific carbohydrate meal (Richardson
et al 1976)." |
| Entered by |
Uri M |
| ID |
110514 |