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List of proteins examined and their turnover rate constants

Range	0.05 - 0.20 Table - link 1/hour
Organism	Bacteria Streptomyces coelicolor
Reference	Jayapal, K.P., Sui, S., Philp, R.J., Kok, Y.J., Yap, M.G., Griffin, T.J., and Hu, W.S. (2010) Multitagging proteomic strategy to estimate protein turnover rates in dynamic systems. J Proteome Res 9: 2087–2097. pp.2094-2095 table 1PubMed ID20184388
Method	"In an effort to segregate these two underlying mechanisms [protein synthesis and breakdown], a novel multitagging approach was developed based on stable isotope tagging (SILAC) and isobaric tag for relative and absolute quantification (iTRAQ) labelling."
Comments	"Figure 6 shows the distribution of kmultitag values for 115 proteins quantified using SILAC-iTRAQ multitagging approach. The rate constants ranged from about 0.05 h^-1 to over 0.20 h^-1 for some proteins. The median value of kmultitag for the proteins was 0.097 h^-1 while the 25th and 75th percentile values were 0.081 h^-1 and 0.116 h^-1 respectively. This indicates that the majority of the proteins have kmultitag values ranging within a small interval with only a few proteins displaying very high or low rates of degradation. A list of these proteins, their kmultitag values, number of peptide hits and other relevant information are shown in Table 1." See notes beneath table
Entered by	Uri M
ID	110439