| Range |
~20 hours
|
| Organism |
Human Homo sapiens |
| Reference |
Boisvert FM, Ahmad Y, Gierlinski M, Charrière F, Lamont D, Scott M, Barton G, Lamond AI. A quantitative spatial proteomics analysis of proteome turnover in human cells. Mol Cell Proteomics. 2012 Mar11(3):M111.011429. doi: 10.1074/mcp.M111.011429. abstract & p.6 right column 3rd paragraphPubMed ID21937730
|
| Method |
"[Researchers] combine an enhanced pulse SILAC (stable isotope labeling with
amino acids in cell culture) approach with
spatial proteomics to perform a system-wide analysis of protein
turnover in cultured human cells." |
| Comments |
"Approximately
60% of HeLa proteins have 50% turnover values
clustered within 5 h of the average turnover rate of 20 h (Fig.
3, blue lines). However, if [researchers] correct for protein abundance, it
takes 24 h for 50% turnover of the total HeLa proteome,
because a subset of abundant proteins has turnover values
longer than the mean of 20 h." |
| Entered by |
Uri M |
| ID |
109937 |