| Value |
8000
molecules/cell
|
| Organism |
Human Homo sapiens |
| Reference |
Li et al. (2014), System wide analyses have underestimated protein abundances and the importance of
transcription in mammals. PeerJ 2:e270 DOI 10.7717/peerj.270 p.14 2nd paragraphPubMed ID24688849
|
| Primary Source |
Vogel C et al., Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line. Mol Syst Biol. 2010 Aug 24 6 :400. doi: 10.1038/msb.2010.59.PubMed ID20739923
|
| Method |
(Primary source abstract:) "Using measurements of absolute protein and mRNA abundances in cellular lysate from the human Daoy medulloblastoma cell line, [researchers] quantitatively evaluate the impact of mRNA concentration and sequence features implicated in translation and protein degradation on protein expression." |
| Comments |
"Two other systemwide estimates of protein abundance in mammalian cells are, like
Schwanhausser et al.'s (2011), lower than [researchers']. These two reports suggest that the median
abundance protein detected is present at 8,000 (primary source) or 9,700 (Beck et al.,
2011) molecules per cell versus our estimate of 170,000 molecules per cell [BNID 110234]." |
| Entered by |
Uri M |
| ID |
110239 |