Estimated IL-4 gene opening rate in Th2 cells
| Value | 0.23 per hour |
|---|---|
| Organism | Mouse Mus musculus |
| Reference | Mariani, L., Schulz, E. G., Lexberg, M. H., Helmstetter, C., Radbruch, A., Löhning, M., & Höfer, T. (2010). Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression. Molecular systems biology, 6(1). p.4 right column & p.7 right column 4th paragraphPubMed ID20393579 |
| Method | Abstract: "Here, [researchers] study the interleukin-4 gene (il4) in T-helper lymphocytes, combining mathematical modeling with the experimental quantification of expression variability and critical parameters." |
| Comments | P.4 right column: "[Researchers] estimated a gene-opening rate of kG=0.23/h, implying that ~23% of the cells were activated in 1h of maximal TF-binding site occupancy." |
| Entered by | mar.esther23 |
| ID | 110176 |