RNA polymerase I transcription elongation rate
| Range | 40 - 60 nts/sec |
|---|---|
| Organism | Budding yeast Saccharomyces cerevisiae |
| Reference | Woolford JL Jr, Baserga SJ. Ribosome biogenesis in the yeast Saccharomyces cerevisiae. Genetics. 2013 Nov195(3):643-81. doi: 10.1534/genetics.113.153197. p.645 right column 3rd paragraphPubMed ID24190922 |
| Primary Source | French, S. L., Y. N. Osheim, F. Cioci, M. Nomura, and A. L. Beyer, 2003 In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes. Mol. Cell. Biol. 23: 1558–1568. & Kos, M., and D. Tollervey, 2010 Yeast pre-rRNA processing and modification occur cotranscriptionally. Mol. Cell 37: 809–820.PubMed ID12588976, 20347423 |
| Comments | "In a single typical yeast cell generation, an astonishing 200,000 ribosomes are produced. To achieve this, RNA polymerase I maintains an elongation rate of 40– 60 nt/sec (primary sources). The ribosome biogenesis machinery consisting of pre-rRNA processing and preribosome assembly factors must keep up this demanding rate of pre-rRNA synthesis." See BNID 109913 |
| Entered by | Uri M |
| ID | 110023 |