| Value |
200
μM
|
| Organism |
Bacteria Escherichia coli |
| Reference |
Valgepea K, Adamberg K, Nahku R, Lahtvee PJ, Arike L, Vilu R. Systems biology approach reveals that overflow metabolism of acetate in Escherichia coli is triggered by carbon catabolite repression of acetyl-CoA synthetase. BMC Syst Biol. 2010 Dec 1 4: 166. doi: 10.1186/1752-0509-4-166. p.2 left column top paragraphPubMed ID21122111
|
| Primary Source |
Kumari S, Beatty CM, Browning DF, Busby SJ, Simel EJ, Hovel-Miner G, Wolfe AJ. Regulation of acetyl coenzyme A synthetase in Escherichia coli. J Bacteriol. 2000 Aug182(15):4173-9.PubMed ID10894724
|
| Comments |
"Acetic acid can be
metabolized to acetyl-CoA either by the PTA-ACKA
pathway or by acetyl-CoA synthetase (ACS) through an
intermediate acetyl-AMP. The high affinity (Km of 200
µM for acetic acid) ACS scavenges acetate at low concentrations
whereas the low affinity PTA-ACKA pathway
(Km of 7-10 mM) is activated in the presence of
high acetate concentrations [primary source]." |
| Entered by |
Uri M |
| ID |
109945 |