| Value |
24.67
hours
|
| Organism |
Human Homo sapiens |
| Reference |
Boisvert FM, Ahmad Y, Gierlinski M, Charrière F, Lamont D, Scott M, Barton G, Lamond AI. A quantitative spatial proteomics analysis of proteome turnover in human cells. Mol Cell Proteomics. 2012 Mar11(3):M111.011429. doi: 10.1074/mcp.M111.011429. p.6 right column 3rd paragraphPubMed ID21937730
|
| Method |
"[Researchers] combine an enhanced pulse SILAC (stable isotope labeling with
amino acids in cell culture) approach with
spatial proteomics to perform a system-wide analysis of protein
turnover in cultured human cells." |
| Comments |
"[~20 hours, average protein turnover rate, BNID 109937] is close to the cell
doubling time under the growth conditions used which [researchers]
measured to be 24.67 h for HeLa cells growing in the SILAC
medium, consistent with approximate doubling of the protein
content as the cell divides (Fig. 3, red line)." |
| Entered by |
Uri M |
| ID |
109938 |