1.4 - 11 hours
||Budding yeast Saccharomyces cerevisiae
||Papagiannakis A, Niebel B, Wit EC, Heinemann M. Autonomous Metabolic Oscillations Robustly Gate the Early and Late Cell Cycle. Mol Cell. 2017 Jan 19 65(2):285-295. doi: 10.1016/j.molcel.2016.11.018. p.286 right column 2nd paragraphPubMed ID27989441
||Abstract: "Using microfluidics, cell-cycle reporters, and single-cell metabolite measurements, [investigators] found that metabolism of budding yeast is a CDK-independent oscillator that oscillates across different growth conditions, both in synchrony with and also in the absence of the cell cycle. Using environmental perturbations and dynamic single-protein depletion experiments, [they] found that the metabolic oscillator and the cell cycle form a system of coupled oscillators, with the metabolic oscillator separately gating and maintaining synchrony with the early and late cell cycle."
||P.286 right column 2nd paragraph: "To test whether metabolic cycles also occur in other growth conditions, [investigators] subjected yeast to different nutrients and metabolic operations (aerobic fermentation, respiration, and gluconeogenesis), which varied the doubling time in single cells from 1.4 to 11 hr. Despite these different metabolic operations, [they] consistently identified oscillations in the NAD(P)H and ATP levels (Figures S2E–S2J), demonstrating that the metabolic cycles occur regardless of growth conditions."