| Comments |
"After circulating in the blood,
eosinophils migrate into the tissues, probably by diapedesis at
endothelial intercellular junctions by a mechanism involving
cytokines and adhesion molecules. Under normal conditions,
once eosinophils enter the tissues, most do not recirculate. The
tissue life span of eosinophils ranges from 2 to 5 days, depending
partly on the tissue studied. However, cytokines increase
eosinophil survival in vitro to 14 days or longer thus, they likely also prolong eosinophil survival in vivo." |