Rate constant of acetylcholinesterase (ACHE)
| Value | 16000 Sec^-1 |
|---|---|
| Organism | Unspecified |
| Reference | Monika Fuxreiter and Arieh Warshel, Origin of the Catalytic Power of Acetylcholinesterase:? Computer Simulation Studies, J. Am. Chem. Soc., 1998, 120 (1), pp 183–194 DOI: 10.1021/ja972326m p.183 left column top paragraph |
| Primary Source | Rosenberry TL. Acetylcholinesterase. Adv Enzymol Relat Areas Mol Biol. 1975 43: 103-218.PubMed ID891 |
| Comments | "Acetylcholinesterase (ACHE) is a serine hydrolaze that terminates the impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. To accomplish this task the enzyme uses one of the highest rate constants known (primary source) (kcat=1.6?10^4s-1)." See BNID 104100 |
| Entered by | Uri M |
| ID | 109216 |