Kcat for the hydrolysis of acetylcholine by water

Range ~8х10^-10 Sec^-1
Organism Unspecified
Reference Monika Fuxreiter and Arieh Warshel, Origin of the Catalytic Power of Acetylcholinesterase:? Computer Simulation Studies, J. Am. Chem. Soc., 1998, 120 (1), pp 183–194 DOI: 10.1021/ja972326m p.186 right column bottom paragraph
Primary Source Schowen, R. L. In Transition States of Biochemical Processes Gandour, R. D., Schowen, R. L., Eds. Plenum: New York, 1978 p 77.
Comments "A useful definition of the catalytic effect can be obtained when one compares kcat for the hydrolysis of acetylcholine by water ~8?10^-10s-1 (e.g. see primary source) to kcat in the enzyme active site ~1.6?10^4 s-1 [BNID 109216]. By this definition we have a rate enhancement of 2?10^13."
Entered by Uri M
ID 109218