Contribution of integral membrane proteins to total protein mass in HeLa cell
| Value | 7.6 % |
|---|---|
| Organism | Human Homo sapiens |
| Reference | Nagaraj N, Wisniewski JR, Geiger T, Cox J, Kircher M, Kelso J, Pääbo S, Mann M. Deep proteome and transcriptome mapping of a human cancer cell line. Mol Syst Biol. 2011 Nov 8 7: 548. doi: 10.1038/msb.2011.81. p.4 right column 2nd paragraphPubMed ID22068331 |
| Method | Online liquid chromatography coupled to high-resolution MS (mass spectrometry) and MS/MS |
| Comments | "...integral membrane proteins account for 25% of the genome but contribute much less to the transcriptome and the proteome (7.6% of total protein mass). This presumably reflects the often cell type specific functions of these proteins (Lundberg et al, 2010 Ramskold et al, 2009)." |
| Entered by | Uri M |
| ID | 108432 |