Mannitol permeability to Caco-2 cell monolayers

Range 0.38х10^-6 to 3.23х10^-6 cm/sec
Organism Human Homo sapiens
Reference Kataoka M, Iwai K, Masaoka Y, Sakane T, Sakuma S, Yamashita S. Scale-up of in vitro permeation assay data to human intestinal permeability using pore theory. Int J Pharm. 2011 Jul 29 414(1-2):69-76 p.69 right column top paragraphPubMed ID21596118
Primary Source Yazdanian, M., Glynn, S.L., Wright, J.L., Hawi, A., 1998. Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds. Pharm. Res. 15, 1490–1494. AND Rubas, W., Jezyk, N., Grass, G.M., 1993. Comparison of the permeability characteristics of a human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption. Pharm. Res. 10, 113–118. AND Chong, S., Dando, S.A., Soucek, K.M., Morrison, R.A., 1996. In vitro permeability through caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system. Pharm. Res. 13, 120–123.PubMed ID9755906, 8430047, 8668660
Comments Epithelial colorectal adenocarcinoma cells
Entered by Uri M
ID 107227