| Value |
7.8e+7
Years
Range: Figure link - link Years
|
| Organism |
Unspecified |
| Reference |
Wolfenden R, Snider MJ. The depth of chemical time and the power of enzymes as catalysts. Acc Chem Res. 2001 Dec34(12):938-45. p.940 right column 3rd paragraph and p.941 fig.4PubMed ID11747411
|
| Primary Source |
Radzicka A, Wolfenden R. A proficient enzyme. Science. 1995 Jan 6 267(5194):90-3.PubMed ID7809611
|
| Method |
(primary source abstract:) Reactions in quartz tubes at elevated temperatures. |
| Comments |
The last step in
pyrimidine biosynthesis is the decarboxylation of orotidine
5'-phosphate to form UMP. The rate of the spontaneous
reaction, modeled with 1-methylorotic acid, is 2.8?10^-16
s-1 at 25 °C, corresponding to a half-time of 78 million
years (primary source) |
| Entered by |
Uri M |
| ID |
107206 |