| Range |
-7.1 E. coli: -8.8 S. cerevisiae: -8:2 C. elegans kcal/mol
|
| Organism |
Various |
| Reference |
Ghosh K, Dill K. Cellular proteomes have broad distributions of protein stability. Biophys J. 2010 Dec 15 99(12):3996-4002. p.3997 left column 1st paragraph under "Results"PubMed ID21156142
|
| Method |
For E. coli, at 37°C, the average protein has a folding
free energy of <?G>=-11.9RT~-7.1kcal/mol, where
RT is the gas constant multiplied by absolute temperature
(for which researchers used T=300 K here). For yeast (Saccharomyces
cerevisiae (SCE)), for which <L>~475 and a=1.56, the average stability is <?G>=-14.7RT~-8.8kcal/mol. For the worm (Caenorhabditis elegans (CEL)), for which
<L>~425 and a=1.23, the average protein stability is
<?G>=-13.7RT~-8.2kcal/mol. Where <L> is the chain length and in the case of gamma distribution, the protein length variation can be
measured by a shape parameter, a. The lower the a value,
the greater the variation (Zhang 2000). |
| Comments |
The standard deviations of the stability distributions
are 4.3 RT, 7.5 RT, and 7.5 RT for E. coli, yeast, and worm,
respectively. |
| Entered by |
Uri M |
| ID |
107069 |