Transcription termination rates

Range 5.8 to 8.7 Table - link mRNAs/hour
Organism Mammalian tissue culture cell
Reference Darzacq X, Shav-Tal Y, de Turris V, Brody Y, Shenoy SM, Phair RD, Singer RH. In vivo dynamics of RNA polymerase II transcription. Nat Struct Mol Biol. 2007 Sep14(9):796-806 p.804 table 1PubMed ID17676063
Method A microscopic study on the cytomegalovirus (CMV) promoter.
Comments P.801 right column bottom paragraph: "[Investigators] have analyzed the transcriptional process in vivo on a specific gene array in the mammalian nucleus. [Their] methodology allowed direct and independent measurements of the Pol II enzyme and its mRNA product and provided rate constants for separate components of transcription: initiation, elongation and pausing (Table 1 and Supplementary Discussion online)." Values are inverse of termination constants in 5th row of table (note time units).
Entered by Uri M
ID 106381