| Range |
-26.2±0.4 Table - link mV
|
| Organism |
Human Homo sapiens |
| Reference |
Park KS, Mohapatra DP, Misonou H, Trimmer JS. Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. Science. 2006 Aug 18 313(5789):976-9. p.977 table 1PubMed ID16917065
|
| Method |
“To determine how Ca2?+/calcineurin-dependent
modulation of phosphorylation at these sites [seven phosphorylation
sites in Kv2.1]
regulates voltage-dependent gating of Kv2.1,
[researchers] expressed isoforms carrying mutated phosphorylation
sites and wild-type Kv2.1 in
HEK293 cells [Human Embryonic Kidney 293]. Whole-cell patch-clamp was
used to analyze Kv2.1 in untreated cells, and
cells treated with ionomycin, or with AP dialyzed
through the patch pipette.” |
| Comments |
"V½ is the half-maximal steady-state inactivation potential
calculated from the current-voltage (I-V) curve." "The half-maximal conductance (G½) and steady-state inactivation(V½) potentials are detailed in Table 1." See note above table |
| Entered by |
Uri M |
| ID |
105740 |