| Value |
>=1
% per chromosome per generation
|
| Organism |
Human Homo sapiens |
| Reference |
Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature. 1997 Apr 10 386(6625):623-7 p.624 left column top paragraphPubMed ID9121588
|
| Method |
Clones of several cell lines and fusions were expanded through 25 generations before interphase FISH analysis using chromosome-specific centromeric probes. |
| Comments |
P.623 right column bottom paragraph: link . Corrected for the number of chromosomes per cell and assuming that CIN (chromosomal instability) affects all chromosomes equally, this translated into a gain or loss of a chromosome in at least one of every five cell divisions. |
| Entered by |
Uri M |
| ID |
105319 |