Rate of chromosome misegregation in a chromosomally stable cell line (HCT116 or RPE-1)

Value 0.025 % per chromosome per mitosis
Organism Human Homo sapiens
Reference Thompson and Compton, Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol. 2008 Feb 25 180(4):665-72 p.669 left columnPubMed ID18283116
Method Abstract: "In this study, [investigators] use live cell imaging and clonal cell analyses to evaluate the fidelity of chromosome segregation in chromosomally stable and unstable human cells."
Comments P.668 right column: "Nevertheless, the rate of chromosome missegregation in untreated RPE-1 and HCT116 cells is ∼0.025% per chromosome and increases to 0.6–0.8% per chromosome upon the induction of merotely through mitotic recovery from either monastrol or nocodazole treatment (Fig. 3 C). These basal and induced rates of chromosome missegregation are similar to those previously measured in primary human fibroblasts (Cimini et al., 1999)."
Entered by Paul Jorgensen
ID 105283