Chromosome missegregation rates in 3 aneuploid tumor cell lines

Range 0.3-1 % per chromosome per mitosis
Organism Human Homo sapiens
Reference Thompson and Compton, Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol. 2008 Feb 25 180(4):665-72. doi: 10.1083/jcb.200712029 p.669 left columnPubMed ID18283116
Method Abstract: "In this study, [investigators] use live cell imaging and clonal cell analyses to evaluate the fidelity of chromosome segregation in chromosomally stable and unstable human cells."
Comments P.669 left column: "Chromosome missegregation rates in three aneuploid tumor cell lines with CIN [chromosomal instability] range from ∼0.3 to ∼1.0% per chromosome (Fig. 3 C). Depending on the modal chromosome number in each cell line, these cells missegregate a chromosome every cell division (Caco2), every other cell division (MCF-7), or every fifth cell division (HT29). Thus, induction of merotely in otherwise near-diploid cells increases the chromosome missegregation rate to levels equivalent to those of aneuploid tumor cells with CIN."
Entered by Paul Jorgensen
ID 105284