Mean doubling time of the fastest growing tumor in humans, Burkitt lymphoma

Value 66 hours Range: 39-117 hours
Organism Human Homo sapiens
Reference Iversen OH, Iversen U, Ziegler JL, Bluming AZ. Cell kinetics in Burkitt lymphoma. Eur J Cancer. 1974 Mar10(3):155-63. abstract & p.159 table 3PubMed ID4479620
Method Abstract: "The cell kinetics of small pieces of diagnostic biopsies of African cases of Burkitt tumour was studied in 13 cases of primary tumour, 4 cases of recurring tumour and three cases of non-Burkitt lymphosarcomas in short time tissue culture with tritiated thymidine, (3 HTdr) in the medium. The in vivo uptake of 3HTdr was also studied in two patients in Stage IV. The uptake of 3 HTdr by tumour cells in ascites fluid was studied in one patient. In 7 patients Colcemid was given 2–4 hr prior to a biopsy, and the number of Colcemid-arrested mitoses counted. In 4 cutaneous nodules of Burkitt tumour, the actual growth rate was measured. The results were analysed by means of a mathematical tumour growth model (see Appendix by R. Bjerknes)."
Comments Abstract: "The kinetic parameters observed were as follows: actual clinical doubling time 66 hr, labelling index 17.34%, rate of cells entering DNA-synthesis 2.71% per hr, mitotic index 1.27%, rate of cells entering mitosis 1.75% per hr, duration of G1 16.5 hr, duration of DNA-synthesis 6.5 hr, duration of G2 2 hr, duration of mitosis 0.7 hr, potential doubling time based on labelling indices 25.6 hr, potential doubling time based on number of Colcemid arrested mitosis 39.6 hr, cell loss in the G2 phase 30%, total cell loss factor 69% of maximum possible cell gain." P.158 right column top paragraph: "The measurement of the growth of cutaneous nodules gave an average growth rate of 1.05% of all cells per hr and an actual doubting time of 66 hr, with wide variations. The measurements are shown in Table 3." Note-shorter doubling times given in BNID 100685 and 103994. See BNID 103804
Entered by Paul Jorgensen
ID 105219