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P.1953 3rd paragraph: "About 50 percent of all human cancers contain a mutation in p53, so hopes are high that the molecule will provide new insights into
treating the disease. Curing cancer and
curing a bacterial disease are very different problems. A bacterium has a
different metabolism from that of a human cell, so scientists can target a
metabolic pathway that kills the bacterium but has no human counterpart.
Because cancer cells are simply human cells that grow too well, a drug that
kills cancer cells usually kills or weakens normal cells." See D.Kandioler-Eckersberger, 'P53-from benchwork to clinical application' Ersatz-und Ergänzungsmethoden zu Tierversuchen 2000, pp 193-196 p.194 2nd paragraph:"To date, p53 is known to be the most commonly mutated gene in human tumors. Of the 6.5 million people diagnosed with cancer each year worldwide about half have p53 mutations in their tumors (Culotta E. and Koshland D.E., 1993)." |