"Rule of thumb" for transforming one molecule per cell to units of concentration

Value 10 pM
Organism Budding yeast Saccharomyces cerevisiae
Reference Calculated according to cell volume, please see Measurement Method
Method Calculated using Avogadro's constant according to cell volume of 50 µm^3= 5E-14liter (BNID 100452, 100 430). 1 particle/5E-14liter=X particles/liter>>X=2E13particles/liter. 2E13(particles/liter)/6E23(particles/mole) = ~3E-11M=~10 pM. Note: 3e-11M and 1e-11M are on same order of magnitude, allowing approximation.
Comments pM=1e-12Molar. Value above means 1000 molecules/cell=10nM. For 1000molecules/cell=1nM (1molecule=1pM) concentration in eukaryotic cell see Luby-Phelps 2000 PMID 10553280 p.191 top paragraph (this order of magnitude difference than calculation above probably comes from consideration of larger eukaryotic cells).
Entered by Uri M
ID 104518