Ratio of PSSG/PSH in steady state in cytosol
| Value | 1.5E-05 Unitless |
|---|---|
| Organism | Human Homo sapiens |
| Reference | Hansen RE, Roth D, Winther JR. Quantifying the global cellular thiol-disulfide status. Proc Natl Acad Sci U S A. 2009 Jan 13 106(2):422-7.PubMed ID19122143 |
| Method | The equilibrium constant, K, of the reaction PSH+GSSG>><<PSSG+GSH is typically close to 1 (ref 21, 22) and in combination with the reducing environment of the cytosol, steady-state levels of PSSG is expected to be extremely low with a ratio of PSSG/PSH of 1.5 × 10-5. |
| Comments | This implies that the vast majority of PSSG should be found in secretory compartments. |
| Entered by | Uri M |
| ID | 103540 |