Half time (t1/2) for delivery of insulin to the lysosomes of renal proximal tubule
| Value | 8.5 min Range: ±1 min |
|---|---|
| Organism | Rabbit |
| Reference | Nielsen S. Time course and kinetics of proximal tubular processing of insulin. Am J Physiol. 1992 May262(5 Pt 2):F817PubMed ID1590426 |
| Method | Proximal tubular segments (S2) of rabbit kidney were perfused with 125 insulin (from pig) at low concentrations for as long as 90 min.From proximal tubules perfused with 125I-insulin for 30 min and chased for 60 min, a compartmental analysis revealed two compartments. |
| Comments | This is the time insulin moved from endocytic vesicles to lysosomes |
| Entered by | Uri M |
| ID | 103362 |