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Diameter of a synaptic vesicle

Value	41.6 nm Range: ±8.4 nm
Organism	Rat Rattus norvegicus
Reference	Takamori S et al., Molecular anatomy of a trafficking organelle. Cell. 2006 Nov 17 127(4):831-46. DOI: 10.1016/j.cell.2006.10.030 p.836 right column 2nd paragraphPubMed ID17110340
Method	cryoelectron microscopy of shock-frozen and unstained samples imaged directly in vitrified ice
Comments	P.836 right column 2nd paragraph: "To measure vesicle volume, [investigators] employed cryoelectron microscopy of shock-frozen and unstained vesicle samples imaged directly in vitrified ice. Figure 3B shows the histogram of such measurements from 790 vesicles, giving an average diameter of 45.18 nm when all vesicles were included in the analysis and 41.6 ± 8.4 (SD) nm as an average when a few large profiles were eliminated (including only diameters between 30 nm and 56 nm). These measurements are well within the range reported previously from fixed and stained brain sections (Harris and Sultan, 1995)." See BNID 102706, 105557
Entered by	Uri M
ID	102775