| Value |
100
Fold
|
| Organism |
Mouse Mus musculus |
| Reference |
Peaper DR, Cresswell P. Regulation of MHC class I assembly and peptide binding. Annu Rev Cell Dev Biol. 200824:pp. 353PubMed ID18729726
|
| Primary Source |
Garbi N, Tan P, Diehl AD, Chambers BJ, Ljunggren HG, Momburg F, Hämmerling GJ. Impaired immune responses and altered peptide repertoire in tapasin-deficient mice. Nat Immunol. 2000 Sep1(3):234-8 fig. 1cPubMed ID10973281
|
| Method |
generation, by homologous recombination, mice with deficient tapasin expression |
| Comments |
The surface expression of the mouse class I alleles H2-Kb and H2-Db was decreased by approximately 100-fold compared with WT cells but remained 10-fold higher than on TAP-deficient cells. |
| Entered by |
Uri M |
| ID |
102662 |