Hill coefficient for folate induced current and [H]+ concentration
| Value | 0.6 Unitless |
|---|---|
| Organism | Mouse Mus musculus |
| Reference | Umapathy NS, Gnana-Prakasam JP, Martin PM, Mysona B, Dun Y, Smith SB, Ganapathy V, Prasad PD. Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types. Invest Ophthalmol Vis Sci. 2007 Nov48(11):5299-305 Fig. 4PubMed ID17962486 |
| Method | Cloning of Mouse PCFT/HCP1 cDNA, Functional Expression of Mouse PCFT/HCP1 in X. laevis Oocytes, |
| Comments | Hill coefficient is less than 1: Negatively cooperative reaction: Once one ligand molecule is bound to the enzyme, its affinity for other ligand molecules decreases. The data suggest that the transport process involves the influx of one H+ per transport cycle. Folate is a water-soluble vitamin, the cofactors of which are essential for the metabolism of one-carbon groups in biochemical reactions. |
| Entered by | Uri M |
| ID | 102597 |