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Nucleotide substitution rate

Range	0.1-1 substitution per genome per cycle
Organism	HIV
Reference	Wain-Hobson S. Viral burden in AIDS. Nature. 1993 Nov 4366(6450):22.PubMed ID8232532
Primary Source	Pathak VK, Temin HM. Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations. Proc Natl Acad Sci U S A. 1990 Aug87(16):6019-23.PubMed ID2201018
Entered by	Uri M
ID	102376