---

Reproductive Number (number of secondary cases a typical single infected case will cause) for 1918 strain

Range	1.9-4.1 unitless
Organism	Influenza
Reference	Mills CE, Robins JM, Lipsitch M. Transmissibility of 1918 pandemic influenza. Nature. 2004 Dec 16 432(7019):904-6. p.905 left column 2nd paragraphPubMed ID15602562
Method	Researchers estimated R (Reproductive number) by fitting a deterministic SEIR model with homogeneous mixing to the excess pneumonia and influenza (P&I) death curves for 45 cities. Researchers assumed distributions of infectiousness consistent with previous studies (Longini et al., 2004, PMID 15033640) and with viral shedding data (Nicholson et al., Textbook of Influenza, 1998), giving mean latent and infectious periods of 1.9 days and 4.1 days, respectively.
Entered by	Andreas Handel
ID	101621