| Value |
175
mV
Range: ±4.33 mV
|
| Organism |
Mitochondria |
| Reference |
Valdameri G, Herrerias T, Carnieri EG, Cadena SM, Martinez GR, Rocha ME. Importance of the core structure of flavones in promoting inhibition of the mitochondrial respiratory chain. Chem Biol Interact. 2010 Oct 6 188(1):52-8 p.55 fig. 3 (trace 'a') and left column bottom paragraphPubMed ID20654598
|
| Method |
"Effect of flavone on membrane potential (??). The ?? of mitochondrial preparations (0.5 mg/mL) was estimated by fluorescence changes of safranin O (5µmol×L^-1)." |
| Comments |
"Fig. 3 shows the effects of flavone on the membrane potential. In the absence of flavone (control experiment, trace a), a ?? of 175mV built up. Flavone (from 50 to 75 µmol/L) did not change the membrane potential, but at concentrations of 100, 150 and 200 µmol/L it decreased the ?? values to 164, 158 and 154 mV, respectively. The results show that flavone (200 µmol/L) impaired the generation of the membrane potential by 21 mV. These results are consistent with the increase in respiratory state 4 (Fig. 2A)." For strength of electric field across membrane of 3×10^7V/m see BNID 105801 (which gives electric potential range of 150-200mV). See BNID 101103 |
| Entered by |
Ron Milo - Admin |
| ID |
101102 |