Known protein-coding genes

Range ~20,500 Genes
Organism Human Homo sapiens
Reference Clamp M et al., Distinguishing protein-coding and noncoding genes in the human genome. Proc Natl Acad Sci U S A. 2007 Dec 4 104(49):19428-33. abstract & p.19429 left column 2nd paragraphPubMed ID18040051
Method Abstract: "...carefully analyzing the nonconserved ORFs-specifically, their properties in other primates."
Comments Abstract: "The analysis yields, as a by-product, a major revision of the current human catalogs, cutting the number of protein-coding genes to approximately 20,500." P.19429 left column 2nd paragraph: "The results have three important consequences. First, the analysis yields as a by-product a major revision to the human gene catalog, cutting the number of genes from ≈24,500 to ≈20,500. The revision eliminates few valid protein-coding genes while dramatically increasing specificity. Second, the analysis provides a scientifically valid methodology for evaluating future proposed additions to the human gene catalog. Third, the analysis implies that the mammalian protein-coding genes have been largely stable, with relatively little invention of truly novel genes." For 19,735 protein-coding genes in C. elegans see BNID 101364
Entered by Ron Milo - Admin
ID 100399