Structural variation in size and organization of protein-coding genes

Range Table - link
Organism Human Homo sapiens
Reference Tom Strachan & Andrew Read, Human Molecular Genetics, 4th edition 2011 Garland science, Organization of the human genome, Chapter 9 p.265 table 9.4 in link
Comments P.265 2nd paragraph: "Human protein-coding genes show enormous variation in size and internal organization. Size variation: Genes in simple organisms such as bacteria are comparatively similar in size and are usually very short (typically about 1 kb long). In complex eukaryotes, genes can show huge variation in size. Although there is generally a direct correlation between gene and product sizes, there are some striking anomalies. For example, the giant 2.4 Mb dystrophin gene is more than 50 times the size of the apolipoprotein B gene but the dystrophin protein has a linear length (total amino acid number) that is about 80% of that of apolipoprotein B (Table 9.4). A small minority of human protein-coding genes lack introns and are generally small (see note to Table 9.4 for some examples)." See note beneath table
Entered by Uri M
ID 110203