| Value |
2.3E-10
mutation/bp/replication
Range: Table - link mutation/bp/replication
|
| Organism |
Nematode Caenorhabditis elegans |
| Reference |
Drake JW, Charlesworth B, Charlesworth D, Crow JF. Rates of spontaneous mutation. Genetics. 1998 Apr148(4):1667-86. p.1673 Table 5PubMed ID9560386
|
| Method |
Combining mutation rates that have been determined for five loci: Taking the gene sizes as three times the number of codons plus 100 b for regulatory and splicing sequences, using an average C (The variously calculated ratio of total mutations to observed mutations)=3.12, dividing by average number of divisions prior to gamete maturation= 9.1 |
| Comments |
"There are about 8.2 cell divisions ancestral to sperm and about 10.0 ancestral to eggs (Kimble and Ward 1988), so [investigators] will use the average, 9.1. Mutation rates and numbers of codons have been determined for five loci. Taking the gene sizes as three times the number of codons plus 100 b for regulatory and splicing sequences, using an average C = 3.12 to correct for the efficiency of mutation detection (Drake 1991) and dividing by the 9.1 cell divisions per sexual generation, [investigators] obtain µb(unc-22) = 1.17 × 10^-11, µb(unc-54) = 1.68 × 10^-11, µb(unc-93) = 52.4 × 10^-11, µb(unc-105) = 4.54 × 10^-11, and µb(sup-10) = 52.6 × 10^-11 (Greenwald and Horvitz 1980 Karnet al. 1983 Eide and Anderson 1985 Benianet al. 1989 Levin and Horvitz 1992 Liuet al. 1996 C. White and P. Anderson, GenBank accession no. U43891) the mean µb = 2.25 × 10^-10. The total genome size G = 8 × 10^7 (Sulston and Brenner 1974). There are about 1.78 × 10^4 genes (Bird 1995) assuming an average of 10^3 b per gene gives Ge = 1.78 × 10^7. Then µg = 8 × 10^7 × 2.25 × 10^-10 = 0.018 and µeg = 1.78 × 10^7 × 2.25 × 10^-10 = 0.0040. These values are posted in Table 5." For description of parameters see link Range of 1.1?10^-10 to 4.8?10^-9 mutations per site per generation according to PMID 17637734 p.622 right column 3rd paragraph. Genome size of 8X10^7bp given in table. |
| Entered by |
Ron Milo - Admin |
| ID |
100287 |