Difference of the Craig Venter genome from the consensus reference sequence

Range ~1.2% when indels and CNVs are considered: 0.1% when SNPs are considered: ~0.3% when inversions are %
Organism Human Homo sapiens
Reference Naidoo N, Pawitan Y, Soong R, Cooper DN, Ku CS. Human genetics and genomics a decade after the release of the draft sequence of the human genome. Hum Genomics. 2011 Oct5(6):577-622. p.589 left column top paragraphPubMed ID22155605
Primary Source Pang, A.W., MacDonald, J.R., Pinto, D., Wei, J. et al . (2010), ‘Towards a comprehensive structural variation map of an individual human genome’, Genome Biol. Vol. 11, p. R52. doi: 10.1186/gb-2010-11-5-r52.PubMed ID20482838
Comments "Indeed, the DNA sequences of individuals within and between populations are genetically rather more diverse and varied than previously thought. This has been corroborated by a recent study demonstrating that the Craig Venter genome differs from the consensus reference sequence by approximately 1.2 per cent when indels and CNVs are considered, a further 0.1 per cent when SNPs are considered and 0.3 per cent when inversions are considered — a grand total of 1.6 per cent (primary source)." CNV=Copy-number variations
Entered by Uri M
ID 110248