| Range |
10 - 20 %
|
| Organism |
Mouse Mus musculus |
| Reference |
Mauvoisin D et al., Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver. Proc Natl Acad Sci U S A. 2014 Jan 7 111(1):167-72. doi: 10.1073/pnas.1314066111. p.167 right column top paragraphPubMed ID24344304
|
| Primary Source |
[9] Reddy AB, et al. (2006) Circadian orchestration of the hepatic proteome. Curr Biol 16(11):1107–1115. [10] Deery MJ, et al. (2009) Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock. Curr Biol 19(23):2031–2036.PubMed ID16753565, 19913422
|
| Method |
2D gel electrophoresis |
| Comments |
p.167 left column bottom paragraph:"However, comparatively little is known on the temporal accumulation of proteins, despite increasing evidence suggesting that posttranscriptional mechanisms also contribute to circadian rhythms at the protein level (ref 5), including mRNA translation (refs 6–8). Of interest, two medium-scale studies relying on 2D gel electrophoresis to quantify the liver and SCN proteomes in mouse concluded that around 10–20% of expressed proteins accumulate rhythmically during the day (primary sources). Surprisingly, in both cases, many of the rhythmic proteins were encoded by nonrhythmic mRNAs, highlighting that translational or posttranslational circadian regulation underlies the accumulation of the circadian proteome." |
| Entered by |
Uri M |
| ID |
111859 |