Total number of trancripts in cell

Value 36000 unitless
Organism Budding yeast Saccharomyces cerevisiae
Reference Siwiak M, Zielenkiewicz P. A comprehensive, quantitative, and genome-wide model of translation.PLoS Comput Biol. 2010 Jul 29 6(7):e1000865. p.11 out of 15 right column 2nd paragraphPubMed ID20686685
Comments "Two reports provide an independent, yet coherent, estimation of the total number of ribosomes: 187,000±56,000 [BNID 100267] and 200,000 [ref 57] molecules per cell. In this study, [researchers] decided to set W to 200,000. The value of 85% was established for the parameter p, as stated in experimental studies [refs 61,62]. The number of all transcripts in a cell is more problematic. Many contemporary studies assume that a yeast cell contains 15,000 mRNAs per cell on average [refs 27,63], which is based on estimations done over 30 years ago [ref 64]. Current research, based on more up-to-date techniques (e.g., in situ hybridisation or GATC-PCR) argues that the number should be at least doubled [ref 65] or even quadrupled [ref 62]. [Researchers] decided to use the value of X situated between these estimates and equal to 36,000. This number was also confirmed by other studies [Miura et al., 2008 PMID 19040753 p.9 right column 2nd paragraph & p.10 left column 2nd paragraph, method-Generalized Adaptor-Tagged Competitive PCR (GATC-PCR)]." See BNID 102988, 103023
Entered by Uri M
ID 106226