Average cytosolic protein oligomerization state (based on 25 proteins)

Value 4 proteins/complex
Organism Bacteria Escherichia coli
Reference Goodsell DS. Inside a living cell. Trends Biochem Sci. 1991 Jun16(6):203-6 p.203 right column 1st paragraphPubMed ID1891800
Primary Source Albe KR, Butler MH, Wright BE. Cellular concentrations of enzymes and their substrates. J Theor Biol. 1990 Mar 22 143(2):163-95.PubMed ID2200929
Method Ref reports using the concentrations of 25 soluble proteins reported by primary source, p. 178 and 180 table AII-http://kirschner.med.harvard.edu/files/bionumbers/MW%20and%20number%20of%20subunits%20of%20cytosolic%20enzymes.pdf
Comments We counted the number of subunits of 23 enzymes reported by primary source in p. 178 and 180 (omitting 3 enzymes with double data and the citric acid cycle enzymes on p. 180). 3 monomers, 7 dimers, 9 tetramers, 2 hexamers, 1 decamer and 1 dodecamer (12-mer) were counted giving a median of 4 and an average of about 3.8. See BNID 105884
Entered by Ron Milo, Paul Jorgensen, Mike Springer
ID 100020