Number of insulin molecules in insulin granule

Range ~1,000,000 insulin molecule/granule
Organism Human Homo sapiens
Reference Rorsman P, Braun M. Regulation of insulin secretion in human pancreatic islets. Annu Rev Physiol. 2013 75 :155-79. doi: 10.1146/annurev-physiol-030212-183754. p.167 bottom paragraphPubMed ID22974438
Primary Source Rorsman P, Renstrom E. 2003. Insulin granule dynamics in pancreatic ßcells. Diabetologia 46: 1029–45PubMed ID12879249
Method [6?10^23(molecules/mole)?1.8?10^-18(moles)= 1,080,000(molecules)]
Comments "A human insulin granule contains 1.8 attomoles [attomole=10^-18 moles] of insulin (primary source)."
Entered by Uri M
ID 109972