Sum of proteins per logarithmically growing haploid cell

Value 5.3e+7 Copies/cell Range: 3e+7 to 8e+7 Copies/cell
Organism Budding yeast Saccharomyces cerevisiae
Reference von der Haar T. A quantitative estimation of the global translational activity in logarithmically growing yeast cells. BMC Syst Biol. 2008 Oct 16 2:87 doi: 10.1186/1752-0509-2-87. p.8 of 14 right column 3rd paragraphPubMed ID18925958
Comments "The sum of proteins per cell predicted from the curated dataset is about 53 million proteins for a fast-growing haploid yeast cell, with 90% confidence limits of 30–80 million. From the local loss-rates for individual proteins through degradation, the global loss-rate through cell growth, and the local protein abundance data, protein synthesis rates can be calculated for each gene. The cell- wide sum of these rates amounts to about 13,000 (6,500– 19,500) proteins synthesised per cell per second on aver- age throughout the cell cycle, and, if translation initiation and termination are assumed to be loss-free processes, there must consequently also be about 13,000 translation initiation and translation termination events per cell per second." See BNID 106198
Entered by Uri M
ID 104313