Doubling time on mouse footpads

Range 300 – 600 hours
Organism Bacteria Mycobacterium leprae
Reference Gibson B, Wilson DJ, Feil E, Eyre-Walker A. The distribution of bacterial doubling times in the wild. Proc Biol Sci. 2018 Jun 13 285(1880). pii: 20180789. doi: 10.1098/rspb.2018.0789 p.6 left column 4th paragraphPubMed ID29899074
Primary Source [48] Shepard CC. 1960 The experimental disease that follows the injection of human leprosy bacilli into foot-pads of mice. J. Exp. Med. 112, 445–454 [49] Rees RJ. 1964 Limited multiplication of acid-fast bacilli in the foot-pads of mice inoculated with Mycobacterium leprae. Br. J. Exp. Pathol. 45, 207–218 [50] Levy L. 1976 Bactericidal action of dapsone against Mycobacterium leprae in mice. Antimicrob. Agents Chemother. 9, 614–617.PubMed ID19867175, 14140757, 773300
Comments P.6 left column 4th paragraph: "There is also independent evidence that there are some bacteria that divide slowly in their natural environment. The aphid symbiont Buchnera aphidicola is estimated to double every 175–292 h in its host [BNID 115546], and Mycobacterium leprae doubles every 300–600 h on mouse footpads [primary sources], not its natural environment, but one that is probably similar to the human skin."
Entered by Uri M
ID 115547