Pace of replication fork

Range ~1,000 nts/sec
Organism Bacteria Escherichia coli
Reference Rocha EP. The replication-related organization of bacterial genomes. Microbiology. 2004 Jun150(Pt 6):1609-27. p.1610 left column 2nd paragraph & p.1611 right column 3rd paragraphPubMed ID15184548
Primary Source Marians, K. J. (1992). Prokaryotic DNA replication. Annu Rev Biochem 61 , 673–719.PubMed ID1497322
Comments "In each replication fork, a complex with two DNA polymerases replicates the two DNA strands. The pace of the replication fork varies significantly between bacteria. For example, in E. coli the fork progresses at ~1000 nt/s ,in Pyrococcus abyssi at ~300 nt/s (Myllykallio et al., 2000) and in Mycoplasma capricolum at ~100 nt/s (Seto & Miyata, 1998). Thus although the M. capricolum genome is seven times smaller than that of E. coli , it takes longer to be replicated...The replication fork moves at about 600–1000 nt/s (primary source), and to duplicate the average 5Mb E. coli chromosome it takes from 40 to 67 min (Bremer & Dennis, 1996)."
Entered by Uri M
ID 110932