Number of RNA molecules that make up genome of influenza A

Value 8 RNA molecules/genome
Organism Influenza
Reference Steinhauer DA, Skehel JJ. Genetics of influenza viruses. Annu Rev Genet. 2002 36: 305-32. abstract, p.306 top paragraph & p.307 3rd paragraphPubMed ID12429695
Primary Source Bean WJJr , Simpson RW. 1976. Transcriptase activity and genome composition of defective influenza virus. J. Virol. 18: 365–69 & McGeoch D, Fellner P, Newton C. 1976. The influenza virus genome consists of eight distinct RNA species. Proc. Natl. Acad. Sci. USA 73: 3045–49 & Palese P, Schulman JL. 1976. Differences in RNA patterns of influenza A viruses. J. Virol. 17: 876–84 & Pons MW. 1976. A re-examination of influenza single-and double-stranded RNAs by gel electrophoresis. Virology 69: 789–92PubMed ID1255876, 1067600, 1255862, 1258370
Method "With the advent of improved electrophoretic techniques for separating nucleic acids and proteins, it was demonstrated that the influenza A genome consists of eight separate RNA segments (primary sources)"
Comments "Influenza A viruses are lipid-enveloped viruses containing a genome composed of eight strands of negative-sense RNA that encode ten viral proteins. These gene segments are encapsidated in a virally encoded nucleoprotein (NP), and the ribonucleoprotein (RNP) structures are associated with the three subunits of the viral polymerase (PB1, PB2, and PA)."
Entered by Uri M
ID 110377