Cellular Cu budget

Value 5.2e+5 atoms/cell
Organism Budding yeast Saccharomyces cerevisiae
Reference Finney LA, O'Halloran TV. Transition metal speciation in the cell: insights from the chemistry of metal ion receptors. Science. 2003 May 9 300(5621):931-6. p.932 left column bottom paragraphPubMed ID12738850
Primary Source [10] Rae TD, Schmidt PJ, Pufahl RA, Culotta VC, O'Halloran TV. Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase. Science. 1999 Apr 30 284(5415):805-8.PubMed ID10221913
Comments P.932 left column bottom paragraph: "Free metal ions in the cytoplasm? Copper is one of the more toxic of the essential metals, so the proposal that the cellular Cu budget (in Saccharomyces cerevisiae, corresponding to 5.2×10^5 atoms per cell) operates on a “no free metal” principle (primary source), employing metal ion chaperone proteins to allocate Cu to some targets, appeals to common sense." See BNID 108840
Entered by Uri M
ID 108833