| Range |
10^4 to 10^6 Spurious sites per transcription factor
|
| Organism |
Eukaryotes |
| Reference |
Wunderlich Z, Mirny LA. Different gene regulation strategies revealed by analysis of binding motifs. Trends Genet. 2009 Oct25(10):434-40. p.437 left column 2nd paragraphPubMed ID19815308
|
| Method |
Using information
theory and simulations, researchers estimate the lower
bound of the number of such spurious sites or hits
as h=2^(Imin-I), with an average spacing s=2^I between
them |
| Comments |
An average multicellular eukaryotic TF is expected to
have h˜10^4–10^6 spurious sites per genome, which is
reduced to h˜10^3–10^5 accessible sites assuming 90%
chromatinization of the genome or h˜10^2–10^4 assuming
98% chromatinization. In multicellular eukaryotes, spurious sites are expected
to arise by chance every s˜4 kb. See BNID 106213 |
| Entered by |
Uri M |
| ID |
106212 |