Number of spurious transcription factor binding sites per genome

Range 10^4 to 10^6 Spurious sites per transcription factor
Organism Eukaryotes
Reference Wunderlich Z, Mirny LA. Different gene regulation strategies revealed by analysis of binding motifs. Trends Genet. 2009 Oct25(10):434-40. p.437 left column 2nd paragraphPubMed ID19815308
Method Using information theory and simulations, researchers estimate the lower bound of the number of such spurious sites or hits as h=2^(Imin-I), with an average spacing s=2^I between them
Comments An average multicellular eukaryotic TF is expected to have h˜10^4–10^6 spurious sites per genome, which is reduced to h˜10^3–10^5 accessible sites assuming 90% chromatinization of the genome or h˜10^2–10^4 assuming 98% chromatinization. In multicellular eukaryotes, spurious sites are expected to arise by chance every s˜4 kb. See BNID 106213
Entered by Uri M
ID 106212